Two recent sea-going expeditions showed that mud diapirism is a common feature in the accretionary wedge of the Mediterranean Ridge, but unlike in other prisms, it is well expressed Bullet Valve exclusively in the most elevated areas of the Ridge.Three diapiric fields were discovered on the Mediterranean Ridge and informally called, from west to ea
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally.Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to
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The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolerance, whereas
Summary: Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions.We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver metastasis.In contrast, mature high-density neutrophils inhibit the formation of liver metastases.Tr